A Case of Mediastinal Extramedullary Plasmacytoma Associated with Multiple Myeloma

plastic proliferation of plasma cells arising from non-osseous sites, while the neoplastic plasma cells in multiple myeloma patients usually involve the medullary space of bones. Extramedullary plasmacytoma may be primary or secondary to marrow involvement by myeloma. Extramedullary plasmacytoma arising from the mediastinum is known to be extremely rare (1). Herein, we present a rare case of mediastinal EMP that manifested as a large anterior mediastinal mass associated with several pleural nodules and bilateral pleural effusions in a patient with multiple myeloma that involved the thoracic spine and the calvarium.